Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion.

ABSTRACT:

Background

T cell-mediated antitumor immunity has a vital role in cancer prevention and treatment; however, the immune-suppressive tumor microenvironment (TME) constitutes a significant contributor to immune evasion that weakens antitumor immunity. Here, we explore the relationship between nucleus accumbens-associated protein-1 (NAC1), a nuclear factor of the BTB (broad-complex, Tramtrack, bric a brac)/POZ (Poxvirus, and Zinc finger) gene family, and the TME.

Methods

Adoptive cell transfer (ACT) of mouse or human tumor antigen (Ag)-specific CD8⁺ cytotoxic T lymphocytes (CTLs) was tested in an immunocompetent or immunodeficient mouse model of melanoma with or without expression of NAC1. The effects of NAC1 expression on immune evasion in tumor cells were assessed i

SUBMITTER: Ren Y 

PROVIDER: S-EPMC9511653 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature