Shorter versus longer corticosteroid duration and recurrent immune checkpoint inhibitor-associated AKI.

ABSTRACT:

Background

Corticosteroids are the mainstay of treatment for immune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI), but the optimal duration of therapy has not been established. Prolonged use of corticosteroids can cause numerous adverse effects and may decrease progression-free survival among patients treated with ICPis. We sought to determine whether a shorter duration of corticosteroids was equally efficacious and safe as compared with a longer duration.

Methods

We used data from an international multicenter cohort study of patients diagnosed with ICPi-AKI from 29 centers across nine countries. We examined whether a shorter duration of corticosteroids (28 days or less) was associated with a higher rate of recurrent ICPi-AKI or death within 30 days followin

SUBMITTER: Gupta S 

PROVIDER: S-EPMC9511654 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature