Imaging cellular immunotherapies and immune cell biomarkers: from preclinical studies to patients.

ABSTRACT: Cellular immunotherapies have emerged as a successful therapeutic approach to fight a wide range of human diseases, including cancer. However, responses are limited to few patients and tumor types. An in-depth understanding of the complexity and dynamics of cellular immunotherapeutics, including what is behind their success and failure in a patient, the role of other immune cell types and molecular biomarkers in determining a response, is now paramount. As the cellular immunotherapy arsenal expands, whole-body non-invasive molecular imaging can shed a light on their in vivo fate and contribute to the reliable assessment of treatment outcome and prediction of therapeutic response. In this review, we outline the non-invasive strategies that can be tailored toward the molecular imaging

SUBMITTER: Volpe A 

PROVIDER: S-EPMC9511655 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature