Association of CARD8 Activating Polymorphism With Bone Erosion in Cholesteatoma Patients.

ABSTRACT:

Objectives

We compared the incidence of polymorphisms activating the NLRP3 inflammasome between controls and patients with cholesteatoma and its potential association with bone erosion in patients with cholesteatoma.

Methods

This is a case-control study assessing the mutation rates in genes of interest in patients with and without cholesteatoma. A total of 133 saliva samples from control (n = 65) and cholesteatoma (n = 68) patients were collected for DNA extraction. Caspase recruitment domain family member 8 (CARD8) (AA: homozygous wild type, AT: heterozygous, TT: homozygous mutant polymorphism) and NLRP3 (CC: homozygous wild type, CA: heterozygous, AA: homozygous mutant) polymorphisms were analyzed with TaqMan single-nucleotide polymorphism (SNP) quantitative polymerase cha

SUBMITTER: Sangal N 

PROVIDER: S-EPMC9511680 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature