Effect of TCF7L2 on the relationship between lifestyle factors and glycemic parameters: a systematic review.

ABSTRACT:

Background

Among candidate genes related to type 2 diabetes (T2DM), one of the strongest genes is Transcription factor 7 like 2 (TCF7L2), regarding the Genome-Wide Association Studies. We aimed to conduct a systematic review of the literature on the modification effect of TCF7L2 on the relation between glycemic parameters and lifestyle factors.

Methods

A systematic literature search was done for relevant publications using electronic databases, including PubMed, EMBASE, Scopus, and Web of Science, from January 1, 2000, to November 2, 2021.

Results

Thirty-eight studies (16 observational studies, six meal test trials, and 16 randomized controlled trials (RCTs)) were included. Most observational studies had been conducted on participants with non-diabetes showing that TC

SUBMITTER: Hosseinpour-Niazi S 

PROVIDER: S-EPMC9511734 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature