Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

ABSTRACT: The major concept of "oxidative stress" is an excess elevated level of reactive oxygen species (ROS) which are generated from vigorous metabolism and consumption of oxygen. The precise harmonization of oxidative stresses between mitochondria and other organelles in the cell is absolutely vital to cell survival. Under oxidative stress, ROS produced from mitochondria and are the major mediator for tumorigenesis in different aspects, such as proliferation, migration/invasion, angiogenesis, inflammation, and immunoescape to allow cancer cells to adapt to the rigorous environment. Accordingly, the dynamic balance of oxidative stresses not only orchestrate complex cell signaling events in cancer cells but also affect other components in the tumor microenvironment (TME). Immune cells, such as M2

SUBMITTER: Kuo CL 

PROVIDER: S-EPMC9511749 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature