Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice.

ABSTRACT:

Background

The laboratory mouse was domesticated from the wild house mouse. Understanding the genetics underlying domestication in laboratory mice, especially in the widely used classical inbred mice, is vital for studies using mouse models. However, the genetic mechanism of laboratory mouse domestication remains unknown due to lack of adequate genomic sequences of wild mice.

Results

We analyze the genetic relationships by whole-genome resequencing of 36 wild mice and 36 inbred strains. All classical inbred mice cluster together distinctly from wild and wild-derived inbred mice. Using nucleotide diversity analysis, Fst, and XP-CLR, we identify 339 positively selected genes that are closely associated with nervous system function. Approximately one third of these positively s

SUBMITTER: Liu M 

PROVIDER: S-EPMC9511766 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature