Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin.

ABSTRACT: Several hypotheses have been presented on the origin of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from its identification as the agent causing the current coronavirus disease 19 (COVID-19) pandemic. So far, no solid evidence has been found to support any hypothesis on the origin of this virus, and the issue continue to resurface over and over again. Here we have unfolded a pattern of distribution of several mutations in the SARS-CoV-2 proteins in 24 geo-locations across different continents. The results showed an evenly uneven distribution of the unique protein variants, distinct mutations, unique frequency of common conserved residues, and mutational residues across these 24 geo-locations. Furthermore, ample mutations were identified in the evolutionarily conserved inva

SUBMITTER: Hassan SS 

PROVIDER: S-EPMC9511875 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature