Responses and functions of dopamine in nucleus accumbens core during social behaviors.

ABSTRACT: Social behaviors are among the most important motivated behaviors. How dopamine (DA), a "reward" signal, releases during social behaviors has been a topic of interest for decades. Here, we use a genetically encoded DA sensor, GRAB_DA2m, to record DA activity in the nucleus accumbens (NAc) core during various social behaviors in male and female mice. We find that DA releases during approach, investigation and consummation phases of social behaviors signal animals' motivation, familiarity of the social target, and valence of the experience, respectively. Positive and negative social experiences evoke opposite DA patterns. Furthermore, DA releases during mating and fighting are sexually dimorphic with a higher level in males than in females. At the functional level, increasing DA in

SUBMITTER: Dai B 

PROVIDER: S-EPMC9511885 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature