Combining direct current and kilohertz frequency alternating current to mitigate onset activity during electrical nerve block.

ABSTRACT: Objective.Electrical nerve block offers the ability to immediately and reversibly block peripheral nerve conduction and would have applications in the emerging field of bioelectronics. Two modalities of electrical nerve block have been investigated-kilohertz frequency alternating current (KHFAC) and direct current (DC). KHFAC can be safely delivered with conventional electrodes, but has the disadvantage of having an onset response, which is a period of increased neural activation before block is established and currently limits clinical translation. DC has long been known to block neural conduction without an onset response but creates damaging reactive species. Typical electrodes can safely deliver DC for less than one second, but advances in high capacitance electrodes allow DC de

SUBMITTER: Eggers T 

PROVIDER: S-EPMC9511888 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature