Dental caries as a risk factor for bacterial blood stream infection (BSI) in children undergoing hematopoietic cell transplantation (HCT).

ABSTRACT:

Background

Hematopoietic cell transplantation (HCT) is a potentially curative therapy for a wide range of pediatric malignant and nonmalignant diseases. However, complications, including blood stream infection (BSI) remain a major cause of morbidity and mortality. While certain bacteria that are abundant in the oral microbiome, such as S. mitis, can cause BSI, the role of the oral microbial community in the etiology of BSI is not well understood. The finding that the use of xylitol wipes, which specifically targets the cariogenic bacteria S. mutans is associated with reduced BSI in pediatric patients, lead us to investigate dental caries as a risk factor for BSI.

Methods

A total of 41 pediatric patients admitted for allogenic or autologous HCT, age 8 months to

SUBMITTER: Abduweli Uyghurturk D 

PROVIDER: S-EPMC9511999 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature