Calcium/calmodulin-dependent protein kinase II associates with the K⁺ channel isoform Kv4.3 in adult rat optic nerve.

ABSTRACT: Spikes are said to exhibit "memory" in that they can be altered by spikes that precede them. In retinal ganglion cell axons, for example, rapid spiking can slow the propagation of subsequent spikes. This increases inter-spike interval and, thus, low-pass filters instantaneous spike frequency. Similarly, a K⁺ ion channel blocker (4-aminopyridine, 4AP) increases the time-to-peak of compound action potentials recorded from optic nerve, and we recently found that reducing autophosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) does too. These results would be expected if CaMKII modulates spike propagation by regulating 4AP-sensitive K⁺ channels. As steps toward identifying a possible substrate, we test whether (i) 4AP alters optic nerve spike

SUBMITTER: Ogata G 

PROVIDER: S-EPMC9512010 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature