Structural brain morphometry as classifier and predictor of ADHD and reward-related comorbidities

ABSTRACT: Attention deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, and around two-thirds of affected children report persisting problems in adulthood. This negative trajectory is associated with high comorbidity with disorders like obesity, depression, or substance use disorder (SUD). Decreases in cortical volume and thickness have also been reported in depression, SUD, and obesity, but it is unclear whether structural brain alterations represent unique disorder-specific profiles. A transdiagnostic exploration of ADHD and typical comorbid disorders could help to understand whether specific morphometric brain changes are due to ADHD or, alternatively, to the comorbid disorders. In the current study, we studied the brain morphometry of 136 subjects with A

SUBMITTER: van Rooij D 

PROVIDER: S-EPMC9512052 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature