Durable antibody and effector memory T cell responses in breastmilk from women with SARS-CoV-2.

ABSTRACT:

Background

Given that only 25% of pregnant women elect to receive a COVID-19 vaccine, maternal SARS-CoV-2 infection remains an important route of conferring protective passive immunity to breastfed infants of mothers who are not vaccinated.

Methods

We enrolled 30 lactating participants between December 2020 and March 2021 who had a positive PCR-test and their first COVID-19 symptoms within the previous 21 days. Participants were asked to provide serial bilateral milk samples at 12 timepoints (~ every 3 days) over a period of 35 days. A second set of samples was collected at least four months after the beginning of the first set. Participants also were asked to provide their dried blood spots and infant stool samples. All samples were tested for receptor-binding domain (RBD)-

SUBMITTER: Narayanaswamy V 

PROVIDER: S-EPMC9512087 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature