Evolutionary History and Strength of Selection Determine the Rate of Antibiotic Resistance Adaptation.

ABSTRACT: Bacterial adaptation to stressful environments often produces evolutionary constraints whereby increases in resistance are associated with reduced fitness in a different environment. The exploitation of this resistance-cost trade-off has been proposed as the basis of rational antimicrobial treatment strategies designed to limit the evolution of drug resistance in bacterial pathogens. Recent theoretical, laboratory, and clinical studies have shown that fluctuating selection can maintain drug efficacy and even restore drug susceptibility, but can also increase the rate of adaptation and promote cross-resistance to other antibiotics. In this paper, we combine mathematical modeling, experimental evolution, and whole-genome sequencing to follow evolutionary trajectories towards β-lactam resista

SUBMITTER: Cisneros-Mayoral S 

PROVIDER: S-EPMC9512152 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature