Application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis.

ABSTRACT: Hereditary transthyretin amyloidosis is an autosomal dominant form of amyloidosis caused by an abnormality in transthyretin, with various ocular manifestations. Among these, ocular amyloid angiopathy has attracted attention because of its direct link to visual impairment and its correlation with systemic severity. We hypothesized that optical coherence tomography angiographic parameters would be useful biomarkers of amyloidosis systemic severity and investigated their correlation with the systemic severity score. The primary outcome was the correlation between the systemic severity score and choriocapillaris flow deficit percentage. Secondary outcomes were the correlations between the systemic severity score and retinal optical coherence tomography angiographic parameters, including foveal

SUBMITTER: Kakihara S 

PROVIDER: S-EPMC9512205 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature