EXPRESSION AND ACTIVITY OF AMINOTRANSFERASES IN THE LIVER OF STREPTOZOTOCIN-DIABETIC RATS: THE EFFECT OF MIFEPRISTONE.

ABSTRACT:

Context

Interventions that suppress hepatic gluconeogenesis from amino acids may be useful for improving glycemic control in diabetic patients.

Objectives

It was shown that administration of glucocorticoid receptor antagonist Mifepristone (MIF) leads to variously pronounced changes in the alanine-, aspartate-, tyrosine- aminotransferases (ALT, AST, TAT) activity in the liver of experimental animals. It has been suggested that this selective effect of MIF may be related to differences in the expression of the corresponding genes. The aim of the study was to investigate the gene expression and activity of ALT, AST and TAT in the liver of rats with streptozotocin-related diabetes (StD) under the long-term oral MIF administration.

Methods

Male Wistar rats (n=48) with StD

SUBMITTER: Selyatitskaya VG 

PROVIDER: S-EPMC9512388 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature