Effect of excessive gestational weight gain on insulin sensitivity and insulin kinetics in women with overweight/obesity.

ABSTRACT:

Objective

Obesity increases the risk for pregnancy complications and maternal hyperglycemia. The Institute of Medicine developed guidelines for gestational weight gain (GWG) targets for women with overweight/obesity, but it is unclear whether exceeding these targets has adverse effects on maternal glucose metabolism.

Methods

Insulin sensitivity (assessed using the Matsuda Insulin Sensitivity Index), β-cell function (assessed as insulin secretion rate in relation to plasma glucose), and plasma insulin clearance rate were evaluated using a frequently sampled oral glucose tolerance test at 15 and 35 weeks of gestation in 184 socioeconomically disadvantaged African American women with overweight/obesity.

Results

Insulin sensitivity decreased, whereas β-cell function and i

SUBMITTER: Cade WT 

PROVIDER: S-EPMC9512396 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature