Keratinocyte PIEZO1 modulates cutaneous mechanosensation.
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ABSTRACT:
SUBMITTER: Mikesell AR
PROVIDER: S-EPMC9512397 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Publications
Keratinocyte PIEZO1 modulates cutaneous mechanosensation.
Mikesell Alexander R AR Isaeva Olena O Moehring Francie F Sadler Katelyn E KE Menzel Anthony D AD Stucky Cheryl L CL
eLife 20220902
Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte expression of PIEZO1 is critical for normal sensory afferent firing and behavioral responses to mechanical stimuli in mice. ...[more]
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