Bone marrow adipocytes drive the development of tissue invasive Ly6C^high monocytes during obesity.

ABSTRACT: During obesity and high fat-diet (HFD) feeding in mice, sustained low-grade inflammation includes not only increased pro-inflammatory macrophages in the expanding adipose tissue, but also bone marrow (BM) production of invasive Ly6C^high monocytes. As BM adiposity also accrues with HFD, we explored the relationship between the gains in BM white adipocytes and invasive Ly6C^high monocytes by in vivo and ex vivo paradigms. We find a temporal and causal link between BM adipocyte whitening and the Ly6C^high monocyte surge, preceding the adipose tissue macrophage rise during HFD in mice. Phenocopying this, ex vivo treatment of BM cells with conditioned media from BM adipocytes or bona fide white adipocytes favoured Ly6C^high monocyte preponderance. Notabl

SUBMITTER: Boroumand P 

PROVIDER: S-EPMC9512398 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature