Condensins are essential for Pseudomonas aeruginosa corneal virulence through their control of lifestyle and virulence programs.

ABSTRACT: Pseudomonas aeruginosa is a significant opportunistic pathogen responsible for numerous human infections. Its high pathogenicity resides in a diverse array of virulence factors and an ability to adapt to hostile environments. We report that these factors are tied to the activity of condensins, SMC and MksBEF, which primarily function in structural chromosome maintenance. This study revealed that both proteins are required for P. aeruginosa virulence during corneal infection. The reduction in virulence was traced to broad changes in gene expression. Transcriptional signatures of smc and mksB mutants were largely dissimilar and non-additive, with the double mutant displaying a distinct gene expression profile. Affected regulons included those responsible for lifestyle control, primary metabo

SUBMITTER: Zhao H 

PROVIDER: S-EPMC9512581 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature