The Platelet Lipidome Is Altered in Patients with COVID-19 and Correlates with Platelet Reactivity.

ABSTRACT:

Background

 Activated platelets have been implicated in the proinflammatory and prothrombotic phenotype of coronavirus disease 2019 (COVID-19). While it is increasingly recognized that lipids have important structural and signaling roles in platelets, the lipidomic landscape of platelets during infection has remained unexplored.

Objective

 To investigate the platelet lipidome of patients hospitalized for COVID-19.

Methods

 We performed untargeted lipidomics in platelets of 25 patients hospitalized for COVID-19 and 23 noninfectious controls with similar age and sex characteristics, and with comparable comorbidities.

Results

 Twenty-five percent of the 1,650 annotated lipids were significantly different between the groups. The significantly altered part of the pl

SUBMITTER: Schuurman AR 

PROVIDER: S-EPMC9512584 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature