Protein Tyrosine Phosphatase 1B Deficiency in Vascular Smooth Muscle Cells Promotes Perivascular Fibrosis following Arterial Injury.

ABSTRACT:

Background

 Smooth muscle cell (SMC) phenotype switching plays a central role during vascular remodeling. Growth factor receptors are negatively regulated by protein tyrosine phosphatases (PTPs), including its prototype PTP1B. Here, we examine how reduction of PTP1B in SMCs affects the vascular remodeling response to injury.

Methods

 Mice with inducible PTP1B deletion in SMCs (SMC.PTP1B-KO) were generated by crossing mice expressing Cre.ER^T2 recombinase under the Myh11 promoter with PTP1B^flox/flox mice and subjected to FeCl₃ carotid artery injury.

Results

 Genetic deletion of PTP1B in SMCs resulted in adventitia enlargement, perivascular SMA⁺ and PDGFRβ⁺ myofibroblast expansion, and collagen accumulation fo

SUBMITTER: Gogiraju R 

PROVIDER: S-EPMC9512587 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature