Source of human milk (mother or donor) is more important than fortifier type (human or bovine) in shaping the preterm infant microbiome.

ABSTRACT: Milk fortifiers help meet the nutritional needs of preterm infants receiving their mother's own milk (MOM) or donor human milk. We conducted a randomized clinical trial (NCT03214822) in 30 very low birth weight premature neonates comparing bovine-derived human milk fortifier (BHMF) versus human-derived fortifier (H2MF). We found that fortifier type does not affect the overall microbiome, although H2MF infants were less often colonized by an unclassified member of Clostridiales Family XI. Secondary analyses show that MOM intake is strongly associated with weight gain and microbiota composition, including Bifidobacterium, Veillonella, and Propionibacterium enrichment. Finally, we show that while oxidative stress (urinary F2-isoprostanes) is not affected by fortifier type or MOM intake, fecal

SUBMITTER: Kumbhare SV 

PROVIDER: S-EPMC9512671 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature