Proteomic and functional characterization of intra-tumor heterogeneity in human endometrial cancer.

ABSTRACT: Endometrial cancer is one of the most frequently diagnosed gynecological cancers worldwide, and its prevalence has increased by more than 50% over the last two decades. Despite the understanding of the major signaling pathways driving the growth and metastasis of endometrial cancer, clinical trials targeting these signals have reported poor outcomes. The heterogeneous nature of endometrial cancer is suspected to be one of the key reasons for the failure of targeted therapies. In this study, we perform a sequential window acquisition of all theoretical fragment ion spectra (SWATH)-based comparative proteomic analysis of 63 tumor biopsies collected from 20 patients and define differences in protein signature in multiple regions of the same tumor. We develop organoids from multiple biopsies c

SUBMITTER: Jamaluddin MFB 

PROVIDER: S-EPMC9512672 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature