External validation of two mpMRI-risk calculators predicting risk of prostate cancer before biopsy.

ABSTRACT:

Purpose

Risk calculators (RC) aim to improve prebiopsy risk stratification. Their latest versions now include multiparametric magnetic resonance imaging (mpMRI) findings. For their implementation into clinical practice, critical external validations are needed.

Methods

We retrospectively analyzed the patient data of 554 men who underwent ultrasound-guided targeted and systematic prostate biopsies at 2 centers. We validated the mpMRI-RCs of Radtke et al. (RC-R) and Alberts et al. (RC-A), previously shown to predict prostate cancer (PCa) and clinically significant PCa (csPCa). We assessed these RCs' prediction accuracy by analyzing the receiver-operating characteristics (ROC) curve and evaluated their clinical utility using Decision Curve Analysis (DCA), including Net-Benefit

SUBMITTER: Pallauf M 

PROVIDER: S-EPMC9512729 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature