SFRP4⁺ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration.

ABSTRACT: Our understanding of full-thickness endometrial regeneration after injury is limited by an incomplete molecular characterization of the cell populations responsible for the organ functions. To help fill this knowledge gap, we characterized 10,551 cells of full-thickness normal human uterine from two menstrual phases (proliferative and secretory phase) using unbiased single cell RNA-sequencing. We dissected cell heterogeneity of main cell types (epithelial, stromal, endothelial, and immune cells) of the full thickness uterine tissues, cell population architectures of human uterus cells across the menstrual cycle. We identified an SFRP4⁺ stromal cell subpopulation that was highly enriched in the regenerative stage of the human endometria during the menstrual cycle, and the SFRP4

SUBMITTER: Wu B 

PROVIDER: S-EPMC9512788 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature