Involvement of a BH3-only apoptosis sensitizer gene Blm-s in hippocampus-mediated mood control.

ABSTRACT: Mood disorders are an important public health issue and recent advances in genomic studies have indicated that molecules involved in neurodevelopment are causally related to mood disorders. BLM-s (BCL-2-like molecule, small transcript isoform), a BH3-only proapoptotic BCL-2 family member, mediates apoptosis of postmitotic immature neurons during embryonic cortical development, but its role in the adult brain is unknown. To better understand the physiological role of Blm-s gene in vivo, we generated a Blm-s-knockout (Blm-s^-/-) mouse. The Blm-s^-/- mice breed normally and exhibit grossly normal development. However, global depletion of Blm-s is highly associated with depression- and anxiety-related behaviors in adult mutant mice with intact learning and memory capacity.

SUBMITTER: Huang PH 

PROVIDER: S-EPMC9512807 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature