Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis.

ABSTRACT: The therapeutic effect of mesenchymal stem cells (MSCs) on sepsis has been well-known. However, a comprehensive understanding of the relationship between MSCs and macrophages remains elusive. Superparamagnetic iron oxide (SPIO) is one of the most commonly used tracers for MSCs. Our previous study has shown that SPIO enhanced the therapeutic effect of MSCs in a macrophage-dependent manner. However, the fate of SPIO-labeled MSCs (MSC^SPIO) after infusion remains unknown and the direct interaction between MSC^SPIO and macrophages remains unclear. Mice were injected intravenously with MSC^SPIO at 2 h after Escherichia coli infection and sacrificed at different times to investigate their distribution and therapeutic effect. We found that MSC^SPIO homed to

SUBMITTER: Pan Y 

PROVIDER: S-EPMC9512818 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature