Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog- Glypicans interaction.

ABSTRACT: During embryonic development, cell-cell communication is crucial to coordinate cell behavior, especially in the generation of differentiation patterns via morphogen gradients. Morphogens are signaling molecules secreted by a source of cells that elicit concentration-dependent responses in target cells. For several morphogens, cell-cell contact via filopodia-like-structures (cytonemes) has been proposed as a mechanism for their gradient formation. Despite of the advances on cytoneme signaling, little is known about how cytonemes navigate through the extracellular matrix and how they orient to find their target. For the Hedgehog (Hh) signaling pathway in Drosophila, Hh co-receptor and adhesion protein Interference hedgehog (Ihog) and the glypicans Dally and Dally-like-protein (Dlp) interact

SUBMITTER: Aguirre-Tamaral A 

PROVIDER: S-EPMC9512826 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature