Quantification of the actual composition of polymeric nanocapsules: a quality control analysis.

ABSTRACT: Nanocapsules (NCs) are drug delivery nanosystems that contain an oily core, stabilized by a surfactant, and surrounded by a polymeric shell. The assembling of the components is based on physical and physicochemical forces, and, hence, usually, only a fraction of each component is finally part of the NCs' structure, while the remaining amount might be solubilized or forming micelles in the NCs' suspending medium. Usually, reports on the characterization of nanostructures simply indicate the association efficiency of the loaded drugs instead of their complete final composition. In this work, we have developed a liquid chromatography (LC) mass spectrometry (MS) methodology that allows the quantification of all the components of a series of NCs prepared by different techniques, namely DL-α-toc

SUBMITTER: Berrecoso G 

PROVIDER: S-EPMC9512864 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature