Colchicine and coronary heart disease risks: A meta-analysis of randomized controlled clinical trials.

ABSTRACT:

Background

Several trials have considered the safety and clinical benefits of colchicine as a treatment option for secondary prevention in patients with coronary atherosclerotic heart disease (CAD), but its safety and clinical benefits remain controversial. The purpose of this study was to explore the clinical benefits of colchicine, focusing on certain subgroups of patients.

Methods

Randomized controlled trials (RCTs) of colchicine in subjects with acute or chronic CAD compared with controls were included to assess all-cause mortality, non-cardiovascular mortality, gastrointestinal adverse effects, diarrhea, MACE, cardiovascular mortality, MI, stroke, and revascularization. We analyzed the association of cardiovascular, mortality, and gastrointestinal risk with colchicine i

SUBMITTER: Ma Z 

PROVIDER: S-EPMC9512890 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature