P14AS upregulates gene expression in the CDKN2A/2B locus through competitive binding to PcG protein CBX7.

ABSTRACT: Background: It is well known that P16 ^INK4A , P14 ^ARF , P15 ^INK4B mRNAs, and ANRIL lncRNA are transcribed from the CDKN2A/2B locus. LncRNA P14AS is a lncRNA transcribed from antisense strand of P14 ^ARF promoter to intron-1. Our previous study showed that P14AS could upregulate the expression level of ANRIL and P16 ^INK4A and promote the proliferation of cancer cells. Because polycomb group protein CBX7 could repress P16 ^INK4A expression and bind ANRIL, we wonder whether the P14AS-upregulated ANRIL and P16 ^INK4A expression is mediated with CBX7. Results</

SUBMITTER: Li Z 

PROVIDER: S-EPMC9513069 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature