Striatal D1 and D2 receptor availability are selectively associated with eye-blink rates after methylphenidate treatment.

ABSTRACT: Eye-blink rate has been proposed as a biomarker of the brain dopamine system, however, findings have not been consistent. This study assessed the relationship between blink rates, measured after oral placebo) (PL) and after a challenge with oral methylphenidate (MP; 60 mg) and striatal D1 receptor (D1R) (measured at baseline) and D2 receptor (D2R) availability (measured after PL and after MP) in healthy participants. PET measures of baseline D1R ([¹¹C]NNC112) (BL-D1R) and D2R availability ([¹¹C]raclopride) after PL (PL-D2R) and after MP (MP-D2R) were quantified in the striatum as non-displaceable binding potential. MP reduced the number of blinks and increased the time participants kept their eyes open. Correlations with dopamine receptors were only significant for th

SUBMITTER: Demiral SB 

PROVIDER: S-EPMC9513088 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature