Comparative effects of different types of cardioplegia in cardiac surgery: A network meta-analysis

ABSTRACT:

Objective

To compare the outcomes of four types of cardioplegia during cardiac surgery: del Nido (DN), blood cardioplegia (BC), histidine-tryptophan-ketoglutarate (HTK) and St. Thomas.

Methods

Randomized controlled trials (RCTs) and observational cohort studies from 2005 to 2021 were identified in PubMed, Embase, and Cochrane databases. Data were extracted for the primary endpoint of perioperative mortality as well as the following secondary endpoints: atrial fibrillation, renal failure, stroke, use of an intra-aortic balloon pump, re-exploration, intensive care unit stay and hospital stay. A network meta-analysis comparing all four types of cardioplegia was performed, as well as direct meta-analysis comparing pairs of cardioplegia types.

Results

Data were extrac

SUBMITTER: Tan J 

PROVIDER: S-EPMC9513158 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature