Dietary intake of deuterium oxide decreases cochlear metabolism and oxidative stress levels in a mouse model of age-related hearing loss.

ABSTRACT: Age-related hearing loss (ARHL) is the most prevalent sensory disorder in the elderly. Currently, no treatment can effectively prevent or reverse ARHL. Aging auditory organs are often accompanied by exacerbated oxidative stress and metabolic deterioration. Here, we report the effect of deuterated oxygen (D₂O), also known as "heavy water", mouse models of ARHL. Supplementing the normal mouse diet with 10% D₂O from 4 to 9 weeks of age lowered hearing thresholds at selected frequencies in treated mice compared to untreated control group. Oxidative stress levels were significantly reduced and in the cochlear duct of treated vs. untreated mice. Through metabolic flux analysis, we found that D₂O mainly slowed down catabolic reactions, and may delay metabolic dete

SUBMITTER: Hou S 

PROVIDER: S-EPMC9513171 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature