Dynamic Modelling of DNA Repair Pathway at the Molecular Level: A New Perspective

ABSTRACT: DNA is the genetic repository for all living organisms, and it is subject to constant changes caused by chemical and physical factors. Any change, if not repaired, erodes the genetic information and causes mutations and diseases. To ensure overall survival, robust DNA repair mechanisms and damage-bypass mechanisms have evolved to ensure that the DNA is constantly protected against potentially deleterious damage while maintaining its integrity. Not surprisingly, defects in DNA repair genes affect metabolic processes, and this can be seen in some types of cancer, where DNA repair pathways are disrupted and deregulated, resulting in genome instability. Mathematically modelling the complex network of genes and processes that make up the DNA repair network will not only provide insight into how

SUBMITTER: Lecca P 

PROVIDER: S-EPMC9513183 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature