Use of non-vitamin K antagonists oral anticoagulants in atrial fibrillation patients on dialysis

ABSTRACT:

Background

Non-vitamin K antagonist oral anticoagulants (NOACs) showed a benefit-risk profile superior to that of warfarin in atrial fibrillation (AF) patients with mild to moderate chronic kidney disease. However, the effectiveness and safety of NOACs in AF patients with end-stage renal disease (ESRD) on dialysis remain unclear. Therefore, we performed a meta-analysis regarding the effect of NOACs vs. warfarin in AF patients undergoing dialysis.

Methods

A search of the Pubmed and EMBASE databases until November 2021 was performed. Adjusted risk ratios (RRs) and 95%confidence intervals (CIs) were pooled by a random-effects model with an inverse variance method.

Results

Six studies involving 3,744 NOAC- and 26,973 warfarin- users were deemed to meet the criteria.

SUBMITTER: Li W 

PROVIDER: S-EPMC9513185 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature