A missense mutation in ISPD contributes to maintain muscle fiber stability.

ABSTRACT:

Background

Livestock and poultry skeletal muscle development was regulated by a variety of genetic factors playing an essential role in this process. In our de novo sequencing, a missense mutation in ISPD exon 2 showed a selected signature for well-developed muscles. However, the relationship between this mutation and muscle phenotypes remains unclear.

Results

Based on the genotype bias of this missense mutation in gamecock chickens, we compared the cross-section of muscle fibers among the individuals with different genotypes with the results showing a genotype preference of this missense mutation in the chickens with hypertrophic muscle fibers. Comparing TT- and CC-genotype ISPD showed that TT- genotype was associated with heavier skeletal muscle and a better effect on myog

SUBMITTER: Guo L 

PROVIDER: S-EPMC9513258 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature