Near real-time surveillance of safety outcomes in US COVID-19 vaccine recipients aged 12 to 64 years.

ABSTRACT:

Background

Active monitoring of safety outcomes following COVID-19 vaccination is critical to understand vaccine safety and can provide early detection of rare outcomes not identified in pre-licensure trials. We present findings from an early warning rapid surveillance system in three large commercial insurance databases including more than 16 million vaccinated individuals.

Methods

We evaluated 17 outcomes of interest following COVID-19 vaccination among individuals aged 12-64 years in Optum, HealthCore, and CVS Health databases from December 11, 2020, through January 22, 2022, January 7, 2022, and December 31, 2021, respectively. We conducted biweekly or monthly sequential testing and generated rate ratios (RR) of observed outcome rates compared to historical (or expected)

SUBMITTER: Lloyd PC 

PROVIDER: S-EPMC9513329 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature