A metabolic reprogramming-related prognostic risk model for clear cell renal cell carcinoma: From construction to preliminary application

ABSTRACT: Metabolic reprogramming is one of the characteristics of clear cell renal cell carcinoma (ccRCC). Although some treatments associated with the metabolic reprogramming for ccRCC have been identified, remain still lacking. In this study, we identified the differentially expressed genes (DEGs) associated with clinical traits with a total of 965 samples via DEG analysis and weighted correlation network analysis (WGCNA), screened the prognostic metabolism-related genes, and constructed the risk score prognostic models. We took the intersection of DEGs with significant difference coexpression modules and received two groups of intersection genes that were connected with metabolism via functional enrichment analysis. Then we respectively screened prognostic metabolic-related genes from the genes

SUBMITTER:  

PROVIDER: S-EPMC9513462 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature