Reproducibility and Repeatability of Assessment of Myocardial Light Chain Amyloidosis Burden Using ¹⁸F-Florbetapir PET/CT.

ABSTRACT:

Background

¹⁸F-florbetapir PET is emerging as an excellent quantitative tool to quantify cardiac light chain (AL) amyloidosis burden. The primary aim of this study was to determine interobserver reproducibility and intraobserver repeatability, defined per the recommendations of the Quantitative Imaging Biomarker Alliance technical performance group, of PET ¹⁸F-florbetapir retention index (RI) in patients with cardiac AL amyloidosis.

Methods

The study cohort comprised 37 subjects with systemic AL amyloidosis enrolled in the prospective study: Molecular Imaging of Primary Amyloid Cardiomyopathy (clinical trials.gov NCT: 02641145). Using 10 mCi of ¹⁸F-florbetapir, a 60-minute dynamic cardiac scan was acquired. Global and segmental left ventricul

SUBMITTER: Nodoushani A 

PROVIDER: S-EPMC9513526 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature