Delineating the Role of the Urinary Metabolome in the Lithogenesis of Calcium-Based Kidney Stones.

ABSTRACT:

Objective

To delineate the role of the urinary metabolome in the genesis of urinary stone disease (USD).

Methods

Untargeted metabolomics was utilized in comparative analyses of calcium-based stones (CBS) and spot urine samples from patients with a history of USD with or without urinary stone activity based on radiologic imaging. Stone and urine metabolomes were stratified by composition and radiographic stone-activity, respectively. Additionally, we quantified highly abundant metabolites that were present in either calcium oxalate (CaOx) or calcium phosphate (CaPhos) stones and also significantly enriched in the urine of active stone formers (SF) compared to non-active SF. These data were used to delineate either a direct involvement of urinary metabolites in lithogenesis or

SUBMITTER: Agudelo J 

PROVIDER: S-EPMC9513556 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature