ChemBioPort: an online portal to navigate the structure, function and chemical inhibition of the human proteome.

ABSTRACT: Chemical probes are important tools to investigate the function of proteins, evaluate their potential as therapeutic targets and provide chemical starting points for drug discovery. As a result, a growing federation of scientists aims to generate chemical probes for all human druggable proteins. A diverse array of data typically guides target selection and chemical probe discovery: information on protein function can help prioritize targets, domain architecture can provide insight on druggability, structural data enables molecular design and existing chemical ligands can serve as foundation or inspiration for chemical probe development. But these heterogenous data types are dispersed across a variety of public repositories that are difficult to cross-reference by non-experts. We developed

SUBMITTER: Liu L 

PROVIDER: S-EPMC9513561 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature