Preoperative robotic radiosurgery for early breast cancer: Results of the phase II ROCK trial (NCT03520894).

ABSTRACT:

Background and purpose

Preoperative partial breast irradiation (PBI) has got the advantage of treating a well-defined target. We report the results of the phase II ROCK trial (NCT03520894), enrolling early breast cancer (BC) patients treated with preoperative robotic radiosurgery (prRS), in terms of acute and early late toxicity, disease control, and cosmesis.

Material and methods

The study recruited between 2018 and 2021 at our Radiation Oncology Unit. Eligible patients were 50 + years old BC, hormonal receptors positive/human epidermal growth factor receptor 2 negative (HR+/HER2-), sized up to 25 mm. The study aimed to prospectively assess the toxicity and feasibility of a robotic single 21 Gy-fraction prRS in preoperative setting.

Results

A total of 70 patients wer

SUBMITTER: Meattini I 

PROVIDER: S-EPMC9513617 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature