Methamphetamine causes cardiovascular dysfunction via cystathionine gamma lyase and hydrogen sulfide depletion.

ABSTRACT: Methamphetamine (METH) is an addictive illicit drug used worldwide that causes significant damage to blood vessels resulting in cardiovascular dysfunction. Recent studies highlight increased prevalence of cardiovascular disease (CVD) and associated complications including hypertension, vasospasm, left ventricular hypertrophy, and coronary artery disease in younger populations due to METH use. Here we report that METH administration in a mouse model of 'binge and crash' decreases cardiovascular function via cystathionine gamma lyase (CSE), hydrogen sulfide (H₂S), nitric oxide (NO) (CSE/H₂S/NO) dependent pathway. METH significantly reduced H₂S and NO bioavailability in plasma and skeletal muscle tissues co-incident with a significant reduction in flow-mediate

SUBMITTER: Kolluru GK 

PROVIDER: S-EPMC9513700 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature