Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy.

ABSTRACT:

Importance

Women with epilepsy are recommended high doses of folic acid before and during pregnancy owing to risk of congenital anomalies associated with antiseizure medications. Whether prenatal exposure to high-dose folic acid is associated with increases in the risk of childhood cancer is unknown.

Objective

To assess whether high-dose folic acid supplementation in mothers with epilepsy is associated with childhood cancer.

Design, setting, and participants

Observational cohort study conducted with nationwide registers in Denmark, Norway, and Sweden from 1997 to 2017. Analyses were performed during January 10, 2022, to January 31, 2022. Mother-child pairs were identified in medical birth registers and linked with information from patient, prescription, and cancer reg

SUBMITTER: Vegrim HM 

PROVIDER: S-EPMC9513705 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature