Association of Primary and Booster Vaccination and Prior Infection With SARS-CoV-2 Infection and Severe COVID-19 Outcomes.

ABSTRACT:

Importance

Data about the association of COVID-19 vaccination and prior SARS-CoV-2 infection with risk of SARS-CoV-2 infection and severe COVID-19 outcomes may guide prevention strategies.

Objective

To estimate the time-varying association of primary and booster COVID-19 vaccination and prior SARS-CoV-2 infection with subsequent SARS-CoV-2 infection, hospitalization, and death.

Design, setting, and participants

Cohort study of 10.6 million residents in North Carolina from March 2, 2020, through June 3, 2022.

Exposures

COVID-19 primary vaccine series and boosters and prior SARS-CoV-2 infection.

Main outcomes and measures

Rate ratio (RR) of SARS-CoV-2 infection and hazard ratio (HR) of COVID-19-related hospitalization and death.

Results

The median a

SUBMITTER: Lin DY 

PROVIDER: S-EPMC9513711 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature