Evaluation and comparison of antioxidant abilities of five bioactive molecules with C–H and O–H bonds in thermodynamics and kinetics† † Electronic supplementary information (ESI) available: Syntheses of BNAH, F420H, and iAscH− and the 1H NMR spectra are provided. The calculation process of parameters ΔG=XH/X and ΔG=°(XH) for caffeic acid and (+)-catechin are available. The kinetic absorbance decay curves of four HAT reactions BNAH/DPPH , (+)-catechin/DPPH , F420H/DPPH , and caffeic acid/DPPH in acetonitrile at 298 K are also shown. See https://doi.org/10.1039/d2ra04839f

ABSTRACT: In this work, the antioxidant abilities of NADH coenzyme analogue BNAH, F420 reduction prototype analogue F420H, vitamin C analogue iAscH−, caffeic acid, and (+)-catechin in acetonitrile in chemical reactions were studied and discussed. Three physical parameters of the antioxidant XH, homolytic bond dissociation free energy ΔG°(XH), self-exchange HAT reaction activation free energy ΔG≠XH/X, and thermo-kinetic parameter ΔG≠°(XH), were used to evaluate the antioxidant ability of XH in thermodynamics, kinetics, and thermo-kinetics. By comparing ΔG°(XH), ΔG≠XH/X and ΔG≠°(XH) of these five bioactive antioxidants to release hydrogen atoms, it is easy to find that iAscH− is the best hydrogen atom donor both thermodynamically and kinetically among these antioxidants. Caffeic acid is the worst hydr

SUBMITTER: Fu Y 

PROVIDER: S-EPMC9513755 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature