Ignored role of polyphenol in boosting reactive oxygen species generation for polyphenol/chemodynamic combination therapy

ABSTRACT: Chemodynamic therapy (CDT) is a promising tumor-specific treatment, but still suffering insufficient reactive oxygen species (ROS) levels due to its limited efficacy of Fenton/Fenton-like reaction. Polyphenol, as a natural reductant, has been applied to promote the efficacy of Fenton/Fenton-like reactions; however, its intrinsic pro-apoptosis effects was ignored. Herein, a novel CDT/polyphenol-combined strategy was designed, based on Avenanthramide C-loaded dendritic mesoporous silica (DMSN)-Au/Fe3O4 nanoplatforms with folic acid modification for tumor-site targeting. For the first time, we showed that the nanocomplex (DMSNAF-AVC-FA) induced ROS production in the cytoplasm via Au/Fe3O4-mediated Fenton reactions and externally damaged the mitochondrial membrane; simultaneously, the resultan

SUBMITTER: Mao H 

PROVIDER: S-EPMC9513774 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature